Outcome of 234 Pregnancies in 140 Renal Transplant Recipients From Five Middle Eastern Countries.

OBJECTIVE.: To study the pregnancy and offspring outcomes in postrenal transplant recipients. METHODS.: This is a retrospective case-note review study investigating the outcome of 234 pregnancies in 140 renal transplant recipients from five different Middle Eastern countries. RESULTS.: Of the overall pregnancies 74.4% were successful albeit with high prevalences of preterm and Caesarean deliveries (40.8% and 53%, respectively). The mean serum creatinine did not rise significantly during pregnancy in the group as a whole but did so in patients who had serum creatinine of or above 150 mumol/L at the beginning of their pregnancies. The mean birth weight was (2,458 g) with 41.3% of the newborns being of low birth weight (<2,500 g). The prevalences of stillbirths were 7.3% and of spontaneous abortion was 19.3%. Preeclampsia and gestational diabetes were observed in 26.1% and 2% of pregnancies, respectively. CONCLUSIONS.: In the presence of good allograft function, the majority of pregnancies in renal transplant recipients have a good outcome but with increased incidence of preeclampsia, reduced gestational age, and low birth weights. Patients with baseline serum creatinine of above 150 mumol/L have an increased risk of allograft dysfunction resulting from the pregnancy.

Al Duraihimh H, Ghamdi G, Moussa D, Shaheen F, Mohsen N, Sharma U, Stephan A, Alfie A, Alamin M, Haberal M, Saeed B, Kechrid M, Al-Sayyari A.

1 Department of Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia. 2 Department of Medicine, Riyadh Armed Forces Hospital, Riyadh, Saudi Arabia. 3 Department of Medicine, Jeddah Kidney Centre, Jeddah, Saudi Arabia. 4 Department of Medicine, Royal Hospital, Muscat, Oman. 5 Department of Medicine, Rizk Hospital, Beirut, Lebanon. 6 Department of Medicine, King Abdulaziz Hospital and Oncology Centre, Jeddah, Saudi Arabia. 7 Department of Surgery, Baçskent University, Ankara, Turkey. 8 Department of Medicine, Kidney Hospital, Damascus, Syria. 9 Department of Medicine, Security Forces Hospital, Riyadh, Saudi Arabia. 10 Department of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.