BIOMEDICAL ARTICLES
Activation of the Renin-Angiotensin system and chronic hypoxia of the kidney.
Recent studies emphasize the role of chronic hypoxia in the kidney as a final common pathway to end-stage renal failure (ESRD). Hypoxia of tubular cells leads to apoptosis or epithelial-mesenchymal transdifferentiation, which in turn exacerbates the fibrosis of the kidney with the […]
Large-Scale Candidate Gene Approach to Identifying Hypertension-Susceptible Genes.
(Hypertens Res 2008; 31: 173-174).
Miyata T.
National Cardiovascular Center Research Institute.
Response to: Left Ventricular Diastolic Dysfunction as Assessed by Echocardiography in Metabolic Syndrome.
Masugata H, Senda S.
Department of Integrated Medicine, Kagawa University.
Left ventricular diastolic dysfunction as assessed by echocardiography in metabolic syndrome.
Song ZZ.
Department of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University.
Attenuation of Focal Brain Ischemia by Telmisartan, an Angiotensin II Type 1 Receptor Blocker, in Atherosclerotic Apolipoprotein E-Deficient Mice.
The effects of an angiotensin II (Ang II) type 1 (AT(1)) receptor blocker (ARB) on focal brain ischemia and atherosclerotic lesions were explored in atherosclerotic apolipoprotein E-deficient (ApoEKO) mice treated with a high-cholesterol diet […]
Akt-FOXO3a Signaling Affects Human Endothelial Progenitor Cell Differentiation.
Here we address the effect of Akt signaling on endothelial progenitor cells (EPCs). Human peripheral blood mononuclear cells (PBMCs) were cultured on fibronectin-coated dishes in EPC differentiation medium. PBMCs differentiated in a series of three steps: proliferation for foci formation, tight attachment to the dishes […]
A Water-Soluble Fullerene Vesicle Alleviates Angiotensin II-Induced Oxidative Stress in Human Umbilical Venous Endothelial Cells.
A water-soluble fullerene vesicle based on the Buckminsterfullerene molecule (Ph(5)C(60)K, denoted as PhK) was explored to determine its effects on anti-oxidation of human umbilical endothelial cells (HUVEC) exposed to exogenous and endogenous reactive oxygen species (ROS). Hydrogen peroxide […]
Effect of Telmisartan, Angiotensin II Receptor Antagonist, on Metabolic Profile in Fructose-Induced Hypertensive, Hyperinsulinemic, Hyperlipidemic Rats.
The metabolic syndrome (MS) is a common risk factor for cardiovascular disease and type-2 diabetes. Recently, telmisartan, an angiotensin II receptor antagonist that has an antihypertensive effect, has been reported to be a partial peroxisome proliferator-activated receptor […]
Chronic Insulin Infusion Normalizes Blood Pressure and the Gene Expressions of Angiotensin II Type 1 Receptor in Fructose-Fed Rats.
It remains open to debate whether hyperinsulinemia leads to the development of hypertension. We addressed this issue by investigating the effect of chronic insulin infusion on blood pressure and related parameters in hypertensive fructose-fed […]
Effects of Pioglitazone on Nitric Oxide Bioavailability Measured Using a Catheter-Type Nitric Oxide Sensor in Angiotensin II-Infusion Rabbit.
Recently, peroxisome proliferator-activated receptor gamma (PPARgamma) ligands have been reported to increase nitric oxide (NO) bioavailability in vitro but not in vivo because of the difficulty of measuring plasma NO. Here, we investigated the effects […]
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