BIOMEDICAL ARTICLES
Mucosal Intraepithelial T-lymphocytes in Refractory Celiac Disease: A Neoplastic Population With a Variable CD8 Phenotype.
Celiac disease (CD) is characterized by villous atrophy and an increase in intraepithelial lymphocytes (IEL). The IEL usually exhibit a suppressor/cytotoxic phenotype (CD3 and CD8) and display a polyclonal profile for T-cell receptor (TCR) rearrangement as opposed to […]
Pharmacokinetic/Pharmacodynamic Drug Interaction Between Rosiglitazone and Mycophenolate Mofetil in Kidney Transplantation: A Case Report.
Cattaneo D, Bitto A, Baldelli S, Cortinovis M, Gotti E, Perico N, Remuzzi G.
Department of Medicine and Transplantation, Azienda Ospedaliera Ospedali Riuniti, Bergamo and Mario Negri Institute for Pharmacological Research, Bergamo, Italy, Center for Research on Organ Transplantation, […]
Retraction: Peritransplant Tolerance Induction with Anti-CD3-Immunotoxin: A Matter of Proinflammatory Cytokine Control.
Thomas JM, Contreras JL, Wang PX, Eckhoff DE, Asiedu C, Hubbard WJ, Cartner S, Thomas FT, Robbin ML, Nadler S, Cook WJ, Sharff J, Neville DM Jr, Shiloach J.
Transplant Immunology Section, Department of Surgery, University of Alabama at Birmingham, Birmingham, […]
Similar Long-Term Outcomes for Laparoscopic Versus Open Live-Donor Nephrectomy Kidney Grafts: An OPTN Database Analysis of 5532 Adult Recipients.
Prior studies that included both adult and pediatric recipients suggested slower early graft function for laparoscopically (vs. openly) procured live donor kidney grafts (LD-Ktxs). Any potential long-term impact, however, remains unknown. We compared long-term […]
Induction of NKG2D Ligands by Gamma Radiation and Tumor Necrosis Factor-alpha May Participate in the Tissue Damage During Acute Graft-Versus-Host Disease.
Immunopathology of acute graft-versus-host disease (aGVHD) involves secretion of proinflammatory cytokines with subsequent expression of danger signals by injured host tissues. This explanation, however, does not explain the cluster of aGVHD target […]
Bioluminescence Imaging Visualizes Activation of Nuclear Factor-kappaB in Mouse Cardiac Transplantation.
BACKGROUND.: The purpose of the current study was to evaluate the role of bioluminescence imaging (BLI) in the determination of nuclear factor (NF)-kappaB activation in cardiac allograft rejection and ischemia-reperfusion injury. METHODS.: To visualize NF-kappaB activation, luciferase transgenic mice under the control […]
SV40 Infection Associated With Rituximab Treatment After Kidney Transplantation in Nonhuman Primates.
BACKGROUND.: A regimen consisting of polyclonal anti-T-cell antibody, sirolimus (SRL), and donor bone marrow (DBM) infusion induces robust transplantation tolerance to skin allografts in mice. We investigated the effect of a similar regimen in a nonhuman primate (NHP) model. METHODS.: Cynomolgus […]
Novel Immunosuppression: R348, a JAK3- and Syk-Inhibitor Attenuates Acute Cardiac Allograft Rejection.
BACKGROUND.: Janus kinase (JAK)3 is crucial for signal transduction downstream of various cytokine receptors in immune cells. This is the first report on the novel JAK3 inhibitor R348. METHODS.: (1) Detailed pharmacokinetic data were obtained in rats; (2) multiple in vitro […]
Alleviating Intestinal Ischemia-Reperfusion Injury in an In Vivo Large Animal Model: Developing an Organ-Specific Preservation Solution.
INTRODUCTION.: This study investigated the role of a novel nutrient-rich preservation solution in alleviating intestinal ischemia-reperfusion (IR) injury in a large animal model. MATERIALS AND METHODS.: Porcine intestines were treated in vivo with the following intraluminal flush […]
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