Prevention and Inhibition But Not Reversion of Chronic Allograft Vasculopathy by FK778.
BACKGROUND.: This study aimed at investigating the efficacy of the novel immunosuppressant FK778 to prevent the development and progression of chronic allograft vasculopathy (CAV). METHODS.: Orthotopic aortic transplantations were performed in the PVG-to-ACI rat model and followed over the course of […]

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Intraoperative blood salvage during liver transplantation in patients with hepatocellular carcinoma: efficiency of leukocyte depletion filters in the removal of tumor cells.
BACKGROUND.: Intraoperative blood salvage (IBS) reduces homologous transfusion in orthotopic liver transplantation (OLT), but may carry with it the risk of reinfusing tumor cells in patients with hepatocellular carcinoma (HCC). The […]

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Limited Benefit of Biochemical Response to Combination Therapy for Patients With Recurrent Hepatitis C After Living-Donor Liver Transplantation.
BACKGROUND.: Effective management of patients with recurrent hepatitis C after liver transplantation has not been established. In this study, we tested the significance of biochemical response (BR) as well as sustained virological response (SVR) to […]

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Successful Treatment of BK Viremia Using Reduction in Immunosuppression Without Antiviral Therapy.
BACKGROUND.: Treatment of BK virus (BKV) infection in renal transplant recipients remains controversial. This retrospective analysis evaluated efficacy and safety of reducing immunosuppression without antiviral therapy. METHODS.: This single center analysis included 24 patients diagnosed with BK viremia between September 2001 […]

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ABO Blood Group-Related Waiting List Disparities in Liver Transplant Candidates: Effect of the MELD Adoption.
BACKGROUND.: Blood group O candidates remain on the waiting list for a liver transplant for a longer time than candidates of other blood groups. Herein, we analyzed potential factors affecting waiting times in the period that preceded the […]

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Outcome of 234 Pregnancies in 140 Renal Transplant Recipients From Five Middle Eastern Countries.
OBJECTIVE.: To study the pregnancy and offspring outcomes in postrenal transplant recipients. METHODS.: This is a retrospective case-note review study investigating the outcome of 234 pregnancies in 140 renal transplant recipients from five different Middle Eastern countries. RESULTS.: Of […]

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Serum Testosterone Levels After Cardiac Transplantation.
BACKGROUND.: Men undergoing heart transplantation during the early 1990s had declines in testosterone associated with rapid bone loss. It is unclear whether low testosterone still occurs in an era of lower prednisone doses, whether cyclosporine A (CsA) contributes, whether hypothalamic-pituitary-gonadal (HPG) suppression or direct testicular effects are […]

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Asymmetric Dimethylarginine and Cardiac Allograft Vasculopathy Progression: Modulation by Sirolimus.
BACKGROUND.: Cardiac allograft vasculopathy (CAV) is a major cause of death after heart transplantation (HT). The reduced bioavailability of endothelium-derived nitric oxide may play a role in endothelial vasodilator dysfunction and thus in the structural changes characterizing CAV. A potential contributor to endothelial […]

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Multicenter, Randomized Study of the Use of Everolimus With Tacrolimus After Renal Transplantation Demonstrates its Effectiveness.
BACKGROUND.: Clinical data are lacking concerning concomitant administration of everolimus and tacrolimus in renal transplant recipients. METHODS.: In a prospective, multicenter, open-label, exploratory, randomized, 6-month study, 92 de novo renal transplant patients received everolimus, steroids, and basiliximab […]

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Acute Renal Allograft Rejection: Diagnostic Significance of Focal Peritubular Capillary C4d.
BACKGROUND.: Focal PTC C4d staining in acute renal allograft rejection has not been studied extensively. METHODS.: Renal allograft biopsies performed after October 2003, representing the first episode of acute rejection (AR) in recipients with >/= 12 months follow-up postbiopsy, were assessed for […]

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