BIOMEDICAL ARTICLES
Haplotype-Based Case-Control Study of Estrogen Receptor alpha (ESR1) Gene and Pregnancy-Induced Hypertension.
Hypotheses about pregnancy-induced hypertension (PIH) have been proposed to explain the vascular damage that characterizes this disease. Reports indicate that estrogens and estrogen receptors play important physiological roles in cardiovascular diseases. There have been studies examining the association between coronary artery […]
Relationship between Blood Pressure and Chronic Kidney Disease in the Japanese Population: The Lower the Better Even in Individuals without Hypertension?
In hypertensive subjects, it has been demonstrated that the lower the blood pressure, the lower the incidence of chronic kidney disease (CKD). However, whether this relationship holds true in individuals without hypertension-that […]
Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension.
A multiple candidate-gene approach was used to investigate not only candidate genes, but also candidate pathways involved in the regulation of blood pressure. We evaluated 307 single nucleotide polymorphisms (SNPs) in 307 genes and […]
A newly estimated glomerular filtration rate is independently associated with arterial stiffness in Japanese patients.
Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease, and thus is a major worldwide public health problem. Recently, an estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease equation […]
Diurnal blood pressure variation in patients with sleep apnea syndrome.
Sleep apnea syndrome (SAS) is an important risk factor for hypertension and cardiovascular diseases. Diurnal blood pressure (BP) changes are evaluated by 24 h ambulatory blood pressure monitoring (ABPM). The purpose of this study was to clarify the relationship between diurnal BP variation […]
Activation of the Renin-Angiotensin system and chronic hypoxia of the kidney.
Recent studies emphasize the role of chronic hypoxia in the kidney as a final common pathway to end-stage renal failure (ESRD). Hypoxia of tubular cells leads to apoptosis or epithelial-mesenchymal transdifferentiation, which in turn exacerbates the fibrosis of the kidney with the […]
Large-Scale Candidate Gene Approach to Identifying Hypertension-Susceptible Genes.
(Hypertens Res 2008; 31: 173-174).
Miyata T.
National Cardiovascular Center Research Institute.
Response to: Left Ventricular Diastolic Dysfunction as Assessed by Echocardiography in Metabolic Syndrome.
Masugata H, Senda S.
Department of Integrated Medicine, Kagawa University.
Left ventricular diastolic dysfunction as assessed by echocardiography in metabolic syndrome.
Song ZZ.
Department of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University.
Attenuation of Focal Brain Ischemia by Telmisartan, an Angiotensin II Type 1 Receptor Blocker, in Atherosclerotic Apolipoprotein E-Deficient Mice.
The effects of an angiotensin II (Ang II) type 1 (AT(1)) receptor blocker (ARB) on focal brain ischemia and atherosclerotic lesions were explored in atherosclerotic apolipoprotein E-deficient (ApoEKO) mice treated with a high-cholesterol diet […]
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