BIOMEDICAL ARTICLES
First trimester diagnosis of sirenomelia: a case report and review of the literature.
Sirenomelia sequence is a rare lethal pattern of congenital anomalies characterized by a number of hallmark skeletal anomalies, including fusion of the lower extremities or a single lower limb, bilateral renal agenesis or dysgenesis with absent or hypoplastic renal arteries, […]
[(18)F]Fluorinated estradiol derivatives for oestrogen receptor imaging: impact of substituents, formulation and specific activity on the biodistribution in breast tumour-bearing mice.
PURPOSE: The biodistribution and tumour uptake of a series of 16alpha-[(18)F]fluoroestradiol ([18F]FES) derivatives was determined in oestrogen receptors-positive (ER+) tumour-bearing mice to assess the impact of substituents, formulation and specific activity on […]
Rupture of the conjoint tendon at the proximal musculotendinous junction of the biceps femoris long head: a case report.
This case report describes a 20-year-old elite-level Australian Rules football player who suffered three unilateral hamstring injuries within a 2 month period. The first two episodes were managed conservatively. Magnetic resonance imaging following the […]
Non-inhibitory antibodies impede lysosomal storage reduction during enzyme replacement therapy of a lysosomal storage disease.
Enzyme replacement therapy is a treatment option for several lysosomal storage disorders. We reported previously that treatment of a knockout mouse model of the sphingolipid storage disease metachromatic leukodystrophy (MLD) by intravenous injection of recombinant human arylsulfatase A […]
Leukemic transformation of Langerhans cell sarcoma.
A 57-year-old man became aware of left supraclavicular lymph node swelling, which was subsequently diagnosed as Langerhans cell sarcoma, based on a positive immunophenotype for CD1a, S-100 protein, and langerin, and histologically bizarre pleomorphism. The tumor became leukemic 3 months later. Despite intensive chemotherapy, he died of […]
Nonmyeloablative allogeneic bone marrow transplantation of a child with systemic autoimmune disease and lung vasculitis.
Jones OY, Cahill RA.
All Children’s Hospital, 801 Sixth Street South, St. Petersburg, FL, 33701, USA, joneso@allkids.org.
Oligonucleotide Microarray Analysis of Genes Regulating Apoptosis in Chronically Ischemic and Postinfarction Myocardium.
The pathology of cardiomyocyte death during and after myocardial infarction involves both necrosis and apoptosis. Although both mechanisms lead to cell death, participation of apoptosis in this process carries the potential of developing therapies influencing at least part of the […]
A Qualitative Study of Stigma and Discrimination against People Living with HIV in Ho Chi Minh City, Vietnam.
Stigma and discrimination against people living with HIV/AIDS (PLHIV) are a pressing problem in Vietnam, in particular because of propaganda associating HIV with the \”social evils\” of sex work and drug use. There is little […]
Time to Take Stock in HIV/AIDS Prevention.
Kalichman SC.
University of Connecticut, Storrs, CT, USA, seth.k@uconn.edu.
The Nature of Nurture: A Genomewide Association Scan for Family Chaos.
Widely used measures of the environment, especially the family environment of children, show genetic influence in dozens of twin and adoption studies. This phenomenon is known as gene-environment correlation in which genetically driven influences of individuals affect their environments. We conducted the […]