BIOMEDICAL ARTICLES
[An essay on the topicality and problem complex / Ethics of the Reverence for Life.]
Albert Schweitzer developed an egalitarian biocentrism which follows the maxim \”I am life that wants to live, in the midst of life that wants to live\”. Following Schweitzer\’s idea of the Reverence for Life obviously leads to ethical […]
Russia: update on animal experiments and alternatives in education.
Progress continues in Russia with growing awareness and implementation of alternatives in education. Further outreach visits and negotiations for replacement have been made by InterNICHE campaigners. Russian language information resources have been complemented by the distribution of translated freeware physiology and pharmacology alternatives; and […]
An in vitro model for the comparative evaluation of bone seeking pharmaceuticals.
The absence of secured knowledge regarding the binding interaction between bone seeking pharmaceuticals and bone, rules out the possibility of modern rational drug design of novel bone seekers. Hence, the first step in the preclinical evaluation of any new bone seeker […]
In Vitro Evaluation of Human Xenobiotic Toxicity: Scientific Concepts and the Novel Integrated Discrete Multiple Cell Co-Culture (IdMOC) Technology.
In vitro human-based experimental systems represent a relevant preclinical tool for the definition of human xenobiotic properties as human-specific xenobiotic properties, by definition, cannot be detected with nonhuman laboratory animals. For the evaluation of […]
Human hepatocytes as an effective alternative experimental system for the evaluation of human drug properties: general concepts and assay procedures.
Human-based in vitro hepatic experimental systems are now used routinely in drug development. The rationale for the use of humanbased in vitro systems is based on the known species-species differences in drug properties. […]
[Vor- und Nachdenkliches … zum wahren Erfolg des 3R Prinzips.]
Without Summary.
Leist M, Kadereit S, Schildknecht S.
Doerenkamp-Zbinden Lehrstuhl fuer in vitro Methoden zum Tierversuchsersatz, naturwissenschafticheund mathematische Fakultaet, Universitaet Konstanz, Deutschland.
Food for thought … on the real success of 3R approaches.
Without Summary.
Leist M, Kadereit S, Schildknecht S.
Doerenkamp-Zbinden Chair for alternative in vitro methods, Faculty of Natural Sciences ad Mathematics, University of Konstanz, Germany.
[Vor- und Nachdenkliches … zu Tierversuchen.]
Without Summary.
Hartung T.
IHCP/ECVAM, EC Joint Research Centre, Ispra, Italy.
Food for Thought … on Animal Tests.
Without Summary.
Hartung T.
IHCP/ECVAM, EC Joint Research Centre, Ispra, Italy.
Alleviation of the drug-resistant phenotype in idarubicin and cytosine arabinoside double-resistant acute myeloid leukemia cells by indomethacin.
Chemoresistance to anticancer drugs is a major issue in the successful treatment of acute myeloid leukemia (AML). In this study, we developed an AML cell line (AML-2/IDAC) that is resistant to treatment with a combination of […]